Interlaboratory Development and Cross Validation of a Chromatographic Method for Determination of Lumefantrine in Human Plasma-A Proficient Capacity Assessment of Bioanalytical Laboratories in East Africa

Introduction cal support [8]. Due to resource constrains, most analytical laboratories in developing countries lack capacity to develop analytical methods, but can set HPLC methods developed elsewhere. For sustainable monitoring of drug quality and efficacy, availability of well-structured analytical laboratories equipped with trained human resource is a matter of urgency. Emerging bioanalytical laboratories in developing countries have an exclusive role to see that this is achieved despite many challenges facing them. These laboratories are currently equipped with some analytical instruments mostly HPLC systems, but majority has limited capacity to analyze biological samples let alone developing analytical methods. Interlaboratory Development and Cross Validation of a Chromatographic Method for Determination of Lumefantrine in Human Plasma-A Proficient Capacity Assessment of Bioanalytical Laboratories in East Africa